Ser284
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Home > Phosphorylation Site Page: > Ser284  -  CREM (mouse)

Site Information
QGVVMAAsPGsLHsP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450065

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 , 4 ) , mass spectrometry ( 2 ) , mutation of modification site ( 3 ) , phosphoamino acid analysis ( 3 , 4 ) , phosphopeptide mapping ( 3 , 4 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 3 , 4 ) , kidney ( 2 ) , liver ( 2 ) , pancreas ( 2 ) , testis ( 2 )

Upstream Regulation
Putative in vivo kinases:
CDK1 (mouse) ( 3 )
Kinases, in vitro:
CDK1 (mouse) ( 3 , 4 )

Downstream Regulation
Effects of modification on CREM:
activity, inhibited ( 3 )
Effects of modification on biological processes:
transcription, altered ( 3 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

3

de Groot RP, Derua R, Goris J, Sassone-Corsi P (1993) Phosphorylation and negative regulation of the transcriptional activator CREM by p34cdc2. Mol Endocrinol 7, 1495-50
8114763   Curated Info

4

de Groot RP, et al. (1993) Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J 12, 3903-11
8404858   Curated Info