Ser317
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Home > Phosphorylation Site Page: > Ser317  -  C5aR (human)

Site Information
RLRKsLPsLLRNVLt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450056

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 4 , 5 ) , phosphopeptide mapping ( 5 ) , western blotting ( 4 )
Disease tissue studied:
breast cancer ( 2 ) , breast ductal carcinoma ( 2 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 , 2 ) , lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 ) , ovarian cancer ( 2 )
Relevant cell line - cell type - tissue:
breast ( 1 , 2 ) , COS (fibroblast) ( 5 ) , HL60 (myeloid) ( 5 ) , lung ( 3 ) , ovary ( 2 ) , RIN (epithelial) ( 4 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 5 )
Treatments:
C5a ( 5 ) , phorbol_ester ( 5 )

Downstream Regulation
Effects of modification on C5aR:
molecular association, regulation ( 4 )
Induce interaction with:
ARRB1 (human) ( 4 ) , ARRB2 (human) ( 4 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

4

Braun L, Christophe T, Boulay F (2003) Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. J Biol Chem 278, 4277-85
12464600   Curated Info

5

Giannini E, Brouchon L, Boulay F (1995) Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. J Biol Chem 270, 19166-72
7642584   Curated Info