Ser314
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Home > Phosphorylation Site Page: > Ser314  -  C5aR (human)

Site Information
FQGRLRKsLPsLLRN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450055

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phosphopeptide mapping ( 3 ) , western blotting ( 2 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 3 ) , HL60 (myeloid) ( 3 ) , lung ( 1 ) , RIN (epithelial) ( 2 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 3 )
Treatments:
C5a ( 3 ) , phorbol_ester ( 3 )

Downstream Regulation
Effects of modification on C5aR:
molecular association, regulation ( 2 )
Induce interaction with:
ARRB1 (human) ( 2 ) , ARRB2 (human) ( 2 )

References 

1

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

2

Braun L, Christophe T, Boulay F (2003) Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. J Biol Chem 278, 4277-85
12464600   Curated Info

3

Giannini E, Brouchon L, Boulay F (1995) Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. J Biol Chem 270, 19166-72
7642584   Curated Info