Tyr814
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Home > Phosphorylation Site Page: > Tyr814  -  gp130 (human)

Site Information
GILPRQQyFKQNCsQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450054

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 )
Disease tissue studied:
lung cancer, surrounding tissue ( 1 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 3 ) , BaF3 ('B lymphocyte, precursor') ( 2 ) , hepatocyte-liver ( 3 ) , HepG2 (hepatic) ( 2 ) , lung ( 1 ) , lymphocyte-spleen ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , transcription, altered ( 2 )

References 

1

Tucker M (2011) CST Curation Set: 10949; Year: 2011; Biosample/Treatment: tissue, lung/untreated; Disease: lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Schmitz J, et al. (2000) The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction. J Immunol 164, 848-54
10623831   Curated Info

3

Ohtani T, et al. (2000) Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12, 95-105
10661409   Curated Info