Ser13
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Home > Phosphorylation Site Page: > Ser13  -  CDC37 (rat)

Site Information
VWDHIEVsDDEDETH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450034

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 3 ) , [32P] bio-synthetic labeling ( 4 ) , electrophoretic mobility shift ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 3 , 4 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 1 ) , 'brain, cerebellum' ( 1 ) , adipose tissue ( 1 ) , COS (fibroblast) ( 3 , 4 ) , heart ( 1 ) , liver ( 1 ) , lung ( 1 ) , pancreas ( 1 ) , spleen ( 1 ) , stomach ( 1 ) , testis ( 1 ) , thymus ( 1 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (rat) ( 4 )
Kinases, in vitro:
CK2A1 (human) ( 3 ) , CK2A1 (rat) ( 4 ) , CK2A2 (human) ( 2 )
Treatments:
EGF ( 3 ) , TBB ( 4 )

Downstream Regulation
Effects of modification on CDC37:
intracellular localization ( 3 ) , molecular association, regulation ( 3 , 4 )
Induce interaction with:
Akt1 (rat) ( 4 ) , AurB (rat) ( 4 ) , CDK4 (human) ( 3 , 4 ) , ICK (human) ( 4 ) , MAK (human) ( 4 ) , MOK (human) ( 3 , 4 ) , RAF1 (human) ( 3 ) , RAF1 (rat) ( 4 ) , Src (human) ( 3 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Miyata Y, Nishida E (2008) Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37. Mol Cell Biochem 316, 127-34
18566753   Curated Info

3

Miyata Y, Nishida E (2007) Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis. FEBS J 274, 5690-703
17922836   Curated Info

4

Miyata Y, Nishida E (2004) CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol 24, 4065-74
15082798   Curated Info