Ser204
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser204  -  PTPRA iso2 (human)

Site Information
PLLARSPsTNRKYPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447612

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 ) , electrophoretic mobility shift ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 3 ) , phosphoamino acid analysis ( 2 , 3 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , A431 (epithelial) ( 3 ) , BT-20 (breast cell) ( 1 ) , COS (fibroblast) ( 3 ) , SKBr3 (breast cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCD (human) ( 1 )
Treatments:
EGF ( 1 ) , siRNA ( 1 ) , TT-232 ( 3 )

Downstream Regulation
Effects of modification on PTPRA iso2:
enzymatic activity, induced ( 1 , 2 , 3 ) , molecular association, regulation ( 2 , 3 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
cell growth, altered ( 2 )
Induce interaction with:
PIK3CB (human) ( 3 ) , PKCD (human) ( 3 ) , Src (human) ( 2 )
Inhibit interaction with:
GRB2 (human) ( 2 )

References 

1

Wang J, Yu L, Zheng X (2013) PTPα-mediated Src activation by EGF in human breast cancer cells. Acta Biochim Biophys Sin (Shanghai) 45, 320-9
23532252   Curated Info

2

Zheng XM, Resnick RJ, Shalloway D (2002) Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation. J Biol Chem 277, 21922-9
11923305   Curated Info

3

Steták A, Csermely P, Ullrich A, Kéri G (2001) Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta. Biochem Biophys Res Commun 288, 564-72
11676480   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.