Lys386
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Home > Acetylation Site Page: > Lys386  -  p53 (human)

Site Information
RHkkLMFktEGPDsD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486382

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 5 , 6 ) , mutation of modification site ( 4 , 6 )
Disease tissue studied:
colorectal cancer ( 6 ) , colorectal carcinoma ( 6 ) , lung cancer ( 4 , 6 ) , non-small cell lung cancer ( 4 , 6 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
nicotinamide ( 6 ) , trichostatin_A ( 6 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 6 ) , transcription, altered ( 4 , 6 )

References 

1

Zheng S, et al. (2017) Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res 77, 4342-4354
28655792   Curated Info

2

van Dieck J, et al. (2009) Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53. J Mol Biol 394, 922-30
19819244   Curated Info

3

Wu SY, Chiang CM (2009) Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. EMBO J 28, 1246-59
19339993   Curated Info

4

Tian C, et al. (2009) KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol 11, 580-91
19377469   Curated Info

5

Rikova K (2008) CST Curation Set: 5647; Year: 2008; Biosample/Treatment: cell line, NCI-H2228/inhibitor; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989
Curated Info

6

Tang Y, et al. (2008) Acetylation is indispensable for p53 activation. Cell 133, 612-26
18485870   Curated Info

7

Li AG, et al. (2007) An acetylation switch in p53 mediates holo-TFIID recruitment. Mol Cell 28, 408-21
17996705   Curated Info