Lys164
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Home > Ubiquitylation Site Page: > Lys164  -  p53 (human)

Site Information
VRAMAIYkQSQHMTE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486296

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 3 ) , mutation of modification site ( 4 ) , western blotting ( 4 )
Disease tissue studied:
bone cancer ( 4 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on p53:
intracellular localization ( 4 ) , protein degradation ( 4 )

References 

1

Landré V, et al. (2017) Regulation of transcriptional activators by DNA-binding domain ubiquitination. Cell Death Differ 24, 903-916
28362432   Curated Info

2

Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610
27184836   Curated Info

3

Wagner SA, et al. (2011) A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles. Mol Cell Proteomics 10, M111.013284
21890473   Curated Info

4

Nie L, Sasaki M, Maki CG (2007) Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination. J Biol Chem 282, 14616-25
17371868   Curated Info