Lys388
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Home > Ubiquitylation Site Page: > Lys388  -  PR (human)

Site Information
QPPALKIkEEEEGAE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486290

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , T47D (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
CUEDC2 (human) ( 1 )

Downstream Regulation
Effects of modification on PR:
protein degradation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Zhang PJ, et al. (2007) CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. EMBO J 26, 1831-42
17347654   Curated Info

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