Lys31
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Home > Ubiquitylation Site Page: > Lys31  -  TRAF2 (mouse)

Site Information
LGTRLEAkYLCSACk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486266

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
lymphoma ( 2 ) , B cell lymphoma ( 2 )
Relevant cell line - cell type - tissue:
CHO (fibroblast) ( 2 ) , HEK293T (epithelial) ( 1 ) , M12 (B lymphocyte) ( 2 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Treatments:
TNF ( 1 )

Downstream Regulation
Effects of modification on TRAF2:
molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein degradation ( 1 , 2 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
TAB2 (human) ( 1 )

References 

1

Li S, Wang L, Dorf ME (2009) PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol Cell 33, 30-42
19150425   Curated Info

2

Brown KD, Hostager BS, Bishop GA (2002) Regulation of TRAF2 signaling by self-induced degradation. J Biol Chem 277, 19433-8
11909853   Curated Info