Thr59
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr59  -  SREBP-1 (human)

Site Information
AGSGAGGtDPAsPDT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 900975702

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , liver cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 ) , HEK293T (epithelial) ( 1 ) , HepG2 (hepatic) ( 1 ) , MCF-7 (breast cell) ( 1 ) , SW480 (intestinal) ( 1 )

Upstream Regulation
Kinases, in vitro:
PKM (human) ( 1 )

Downstream Regulation
Effects of modification on SREBP-1:
protein stabilization ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
PKM (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
hepatocellular carcinoma ( 1 )

References 

1

Zhao X, et al. (2018) Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma. J Biol Chem
29514980   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.