Ser336
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Home > Phosphorylation Site Page: > Ser336  -  CCR5 (human)

Site Information
QEAPERAssVyTRst   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449901

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , electrophoretic mobility shift ( 4 ) , flow cytometry ( 3 ) , mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 1 ) , phosphoamino acid analysis ( 4 ) , western blotting ( 1 )
Disease tissue studied:
lymphoma ( 3 ) , anaplastic large cell lymphoma ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , CCRF-CEM (T lymphocyte) ( 3 ) , COS (fibroblast) ( 4 ) , HOS (bone cell) ( 3 ) , RBL-2H3 (basophil) [CCR5 (human)] ( 2 ) , RBL-2H3 (basophil) ( 1 , 4 )

Upstream Regulation
Putative in vivo kinases:
GRK3 (human) ( 4 )
Treatments:
AOP-RANTES ( 4 ) , bisindolylmaleimide ( 1 ) , CCL3 ( 3 ) , phorbol_ester ( 1 ) , PTX ( 1 ) , RANTES ( 1 , 4 )

Downstream Regulation
Effects of modification on CCR5:
activity, inhibited ( 2 ) , molecular association, regulation ( 2 ) , receptor desensitization, altered ( 4 ) , receptor internalization, altered ( 2 , 3 , 4 )
Induce interaction with:
ARRB1 (rat) ( 2 ) , ARRB2 (rat) ( 2 )

References 

1

Pollok-Kopp B, Schwarze K, Baradari VK, Oppermann M (2003) Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. J Biol Chem 278, 2190-8
12403770   Curated Info

2

Huttenrauch F, et al. (2002) Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif. J Biol Chem 277, 30769-77
12065593   Curated Info

3

Brandt SM, et al. (2002) Association of chemokine-mediated block to HIV entry with coreceptor internalization. J Biol Chem 277, 17291-9
11782464   Curated Info

4

Oppermann M, Mack M, Proudfoot AE, Olbrich H (1999) Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J Biol Chem 274, 8875-85
10085131   Curated Info

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