Thr121
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Home > Phosphorylation Site Page: > Thr121  -  PTHrP (human)

Site Information
YKEQPLKtPGKKKKG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449879

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 2 ) , flow cytometry ( 2 ) , mutation of modification site ( 2 ) , phosphopeptide mapping ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CDK2 (human) ( 2 )
Kinases, in vitro:
CDK2 (human) ( 2 )

Downstream Regulation
Effects of modification on PTHrP:
intracellular localization ( 1 , 2 ) , molecular association, regulation ( 1 )
Inhibit interaction with:
KPNB1 (human) ( 1 )

References 

1

Cingolani G, Bednenko J, Gillespie MT, Gerace L (2002) Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. Mol Cell 10, 1345-53
12504010   Curated Info

2

Lam MH, et al. (1999) Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization. J Biol Chem 274, 18559-66
10373465   Curated Info