Ser302
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Home > Phosphorylation Site Page: > Ser302  -  PDE3B (rat)

Site Information
GKMFRRPsLPCISRE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449873

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 ) , electrophoretic mobility shift ( 2 ) , phosphopeptide mapping ( 2 , 3 )
Relevant cell line - cell type - tissue:
adipocyte-adipose tissue ( 3 ) , preadipocyte ( 2 )

Upstream Regulation
Kinases, in vitro:
PKACA (rat) ( 3 )
Putative upstream phosphatases:
PPP2CA (rat) ( 2 )
Treatments:
calyculin_A ( 2 ) , insulin ( 2 , 3 ) , isoproterenol ( 3 ) , okadaic_acid ( 2 )

Downstream Regulation
Effects of modification on PDE3B:
enzymatic activity, induced ( 3 ) , molecular association, regulation ( 1 )
Induce interaction with:
14-3-3 beta (mouse) ( 1 )

References 

1

Onuma H, et al. (2002) Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 beta protein. Diabetes 51, 3362-7
12453887   Curated Info

2

Resjö S, et al. (1999) Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A. Biochem J 341 ( Pt 3), 839-45
10417351   Curated Info

3

Rahn T, et al. (1996) Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol. J Biol Chem 271, 11575-80
8626720   Curated Info

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