Ser1412
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Home > Phosphorylation Site Page: > Ser1412  -  nNOS (rat)

Site Information
TNRLRSEsIAFIEES   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449830

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 4 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 2 ) , 'neuron, hippocampal'-'brain, embryonic' ( 2 ) , kidney ( 3 ) , liver ( 4 )

Upstream Regulation
Treatments:
4-AP ( 2 ) , bicuculline ( 2 ) , MK801 ( 2 )

Downstream Regulation
Effects of modification on nNOS:
enzymatic activity, induced ( 5 )

References 

1

Chen X, et al. (2021) Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation. Neuroreport 32, 228-237
33470757   Curated Info

2

Ferreira JM, Burnett AL, Rameau GA (2011) Activity-dependent regulation of surface glucose transporter-3. J Neurosci 31, 1991-9
21307237   Curated Info

3

Mount PF, et al. (2006) Phosphorylation of neuronal and endothelial nitric oxide synthase in the kidney with high and low salt diets. Nephron Physiol 102, p36-50
16244499   Curated Info

4

Elfering SL, Sarkela TM, Giulivi C (2002) Biochemistry of mitochondrial nitric-oxide synthase. J Biol Chem 277, 38079-86
12154090   Curated Info

5

Adak S, et al. (2001) Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis. J Biol Chem 276, 1244-52
11038355   Curated Info