Ser16
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Home > Phosphorylation Site Page: > Ser16  -  AR (human)

Site Information
RVYPRPPsKTYrGAF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449805

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 2 , 4 ) , phospho-antibody ( 1 , 2 , 3 ) , phosphoamino acid analysis ( 4 ) , phosphopeptide mapping ( 4 ) , western blotting ( 1 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
metribolone ( 2 , 3 , 4 ) , okadaic_acid ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
prostate cancer ( 4 )

References 

1

Zboray L, et al. (2015) Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA. Cell Rep 13, 2312-23
26673324   Curated Info

2

Yang CS, et al. (2007) Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions. Mol Cell Biol 27, 3390-404
17325038   Curated Info

3

Yang CS, et al. (2005) Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor. Mol Cell Biol 25, 1298-308
15684382   Curated Info

4

Gioeli D, et al. (2002) Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem 277, 29304-14
12015328   Curated Info