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Site Information |
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VPVARKLsAREQRDC SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 483971 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
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Downstream Regulation | |
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Effects of modification on DRP1: | |
Effects of modification on biological processes: |
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Relevant diseases: |
References | |
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Hao Y, et al. (2024) ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease. Cell Commun Signal 22, 26
38200543 Curated Info |
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Pearah A, et al. (2023) Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity. Cell Chem Biol
37890479 Curated Info |
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Xu H, et al. (2023) Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy. JACC Basic Transl Sci 8, 1215-1239
37791317 Curated Info |
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Zheng M, et al. (2022) Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma. Oncogene
36434180 Curated Info |
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Tao T, et al. (2022) Continued P2X7 activation leads to mitochondrial fission and compromising microglial phagocytosis after subarachnoid haemorrhage. J Neurochem
36269673 Curated Info |
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Hu SL, et al. (2022) TBK1-medicated DRP1 phosphorylation orchestrates mitochondrial dynamics and autophagy activation in osteoarthritis. Acta Pharmacol Sin
36008706 Curated Info |
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Abdullah MO, et al. (2022) Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids. Cell Rep 40, 111198
35977476 Curated Info |
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Li J, et al. (2022) Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function. J Mol Histol
35819738 Curated Info |
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Yu T, Park YM, Wang L, Deuster PA (2022) L-citrulline prevents heat-induced mitochondrial dysfunction and cell injury through nitric oxide-mediated Drp1 inhibition in mouse C2C12 myoblasts. Br J Nutr, 1-24
35791786 Curated Info |
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Kim HS, et al. (2022) Targeting PLD2 in adipocytes augments adaptive thermogenesis by improving mitochondrial quality and quantity in mice. J Exp Med 219
34940790 Curated Info |
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Merz KE, et al. (2022) Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1. Nat Commun 13, 424
35058456 Curated Info |
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Chen YD, et al. (2022) The association between disruption of the circadian rhythm and aggravation of colitis in mice. Gastroenterol Rep (Oxf) 10, goac028
35720196 Curated Info |
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Du J, et al. (2022) AMPK Activation Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating Drp1-Mediated Mitochondrial Dynamics. Front Pharmacol 13, 862204
35860026 Curated Info |
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Soundararajan R, et al. (2022) A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury. Front Pharmacol 13, 980723
36263130 Curated Info |
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Zhao J, et al. (2021) O-GlcNAc Transferase (OGT) Protects Cerebral Neurons from Death During Ischemia/Reperfusion (I/R) Injury by Modulating Drp1 in Mice. Neuromolecular Med
34705256 Curated Info |
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Simula L, et al. (2021) PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism. Mol Oncol 16
34535949 Curated Info |
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Valera-Alberni M, et al. (2021) Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Rep 36, 109565
34433037 Curated Info |
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Cheng D, et al. (2021) Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease. BMC Complement Med Ther 21, 206
34372842 Curated Info |
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Lee KJ, et al. (2021) Cytoprotective Effect of Vitamin D on Doxorubicin-Induced Cardiac Toxicity in Triple Negative Breast Cancer. Int J Mol Sci 22
34299059 Curated Info |
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Xie Y, et al. (2021) GLP-1 improves the neuronal supportive ability of astrocytes in Alzheimer's disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway. Biochem Pharmacol 188, 114578
33895160 Curated Info |
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Li W, et al. (2021) Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics. J Ethnopharmacol 271, 113853
33485986 Curated Info |
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Zhao W, et al. (2021) Estrogen Deficiency Induces Mitochondrial Damage Prior to Emergence of Cognitive Deficits in a Postmenopausal Mouse Model. Front Aging Neurosci 13, 713819
34335235 Curated Info |
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Zhang X, et al. (2020) CaMKIV regulates mitochondrial dynamics during sepsis. Cell Calcium 92, 102286
32932146 Curated Info |
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Liu X, et al. (2020) Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway. Metabolism
32777444 Curated Info |
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Edwards G, et al. (2020) Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Cell Death Dis
32312949 Curated Info |
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Lee DG, et al. (2020) Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. Cell Death Dis 11, 204
32205843 Curated Info |
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Giovarelli M, et al. (2020) Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle. Cell Death Differ
32042098 Curated Info |
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Zhang H, et al. (2020) Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress. PLoS One 15, e0242700
33211772 Curated Info |
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Kim KY, et al. (2019) l-Serine protects mouse hippocampal neuronal HT22 cells against oxidative stress-mediated mitochondrial damage and apoptotic cell death. Free Radic Biol Med 141, 447-460
31326607 Curated Info |
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Zhou X, et al. (2017) Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability. Oncotarget 8, 44682-44693
28591721 Curated Info |
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Xu S, et al. (2016) CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation. Nat Commun 7, 13189
27739424 Curated Info |
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Moriwaki K, et al. (2016) The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. J Immunol 196, 407-15
26582950 Curated Info |
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Kleinridders A, et al. (2015) Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc Natl Acad Sci U S A 112, 3463-8
25733901 Curated Info |
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Cribbs JT, Strack S (2007) Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep 8, 939-44
17721437 Curated Info |