Thr51

Site Information
SVIVADQtPtPtRFL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448224

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 ) , phospho-antibody ( 4 )
Relevant cell line - cell type - tissue:	adipose tissue ( 2 ) , IEC-6 (epithelial) ( 1 ) , kidney ( 2 ) , liver ( 2 , 3 ) , lung ( 2 ) , PC-12 (chromaffin) ( 4 ) , spleen ( 2 )

Upstream Regulation
Regulatory protein:	MTPN (human) ( 4 )
Treatments:	colforsin ( 4 ) , NGF ( 4 )

References
1	Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669 23712012 Curated Info
2	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
3	Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729 21738781 Curated Info
4	Suzuki T, Yamakuni T, Hagiwara M, Ichinose H (2002) Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. J Biol Chem 277, 40768-74 12196528 Curated Info
5	Livingstone C, Patel G, Jones N (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J 14, 1785-97 7737129 Curated Info