Ser568

Site Information
TYRsEVSsPIQRGDV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 483851

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 )
Disease tissue studied:	breast cancer ( 3 , 6 ) , breast ductal carcinoma ( 3 ) , breast cancer, triple negative ( 3 ) , lung cancer ( 4 , 6 ) , non-small cell lung cancer ( 6 ) , non-small cell lung adenocarcinoma ( 4 ) , ovarian cancer ( 3 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:	'stem, embryonic' ( 8 ) , 293 (epithelial) ( 9 ) , breast ( 3 ) , BT-20 (breast cell) ( 6 ) , BT-549 (breast cell) ( 6 ) , H2077 (pulmonary) ( 6 ) , H322M (pulmonary) ( 6 ) , HeLa (cervical) ( 2 , 5 , 7 , 10 ) , HOP62 (pulmonary) ( 6 ) , lung ( 4 ) , MDA-MB-231 (breast cell) ( 6 ) , MDA-MB-468 (breast cell) ( 6 ) , NCI-H1395 (pulmonary) ( 6 ) , NCI-H2030 (pulmonary) ( 6 ) , NCI-H322 (pulmonary) ( 6 ) , ovary ( 3 ) , WM239A (melanocyte) ( 1 )

Upstream Regulation
Treatments:	ischemia ( 3 )

References
1	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
2	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
3	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
4	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
5	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
6	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
7	Zhou J (2010) CST Curation Set: 9275; Year: 2010; Biosample/Treatment: cell line, HeLa/untreated; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y)XpS Curated Info
8	Brill LM, et al. (2009) Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 5, 204-13 19664994 Curated Info
9	Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501 19413330 Curated Info
10	Beausoleil SA, et al. (2006) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol 24, 1285-92 16964243 Curated Info