Thr287

Site Information
KIGFPsttPAKAKAN SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 483203

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 , 4 , 5 , 6 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Disease tissue studied:	lung cancer ( 4 ) , non-small cell lung adenocarcinoma ( 4 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 2 , 3 , 5 , 6 ) , lung ( 4 ) , Vero E6-S ('epithelial, kidney') ( 1 )

Downstream Regulation
Effects of modification on Restin:	intracellular localization ( 3 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:	cell cycle regulation ( 3 )
Induce interaction with:	PLK1 (human) ( 3 )

References
1	Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell 182 32645325 Curated Info
2	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
3	Amin MA, et al. (2014) CLIP-170 recruits PLK1 to kinetochores during early mitosis for chromosome alignment. J Cell Sci 127, 2818-24 24777477 Curated Info
4	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
5	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
6	Beausoleil SA, et al. (2006) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol 24, 1285-92 16964243 Curated Info