Thr2487
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Home > Phosphorylation Site Page: > Thr2487  -  Notch 1 (mouse)

Site Information
VPEHPFLtPSPESPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 483083

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on Notch 1:
molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Induce interaction with:
FBXW7 (human) ( 1 )

References 

1

O'Neil J, et al. (2007) FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med 204, 1813-24
17646409   Curated Info