Lys740
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Home > Acetylation Site Page: > Lys740  -  PAP-alpha (human)

Site Information
PVIkNsIkLRLNR__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 483064

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 2 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
bladder cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
nicotinamide ( 2 ) , siRNA ( 1 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on PAP-alpha:
enzymatic activity, inhibited ( 1 ) , intracellular localization ( 2 ) , molecular association, regulation ( 2 ) , protein stabilization ( 1 )
Inhibit interaction with:
CFIM25 (human) ( 2 ) , CPSF6 (human) ( 2 )

References 

1

Vethantham V, Rao N, Manley JL (2008) Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function. Genes Dev 22, 499-511
18281463   Curated Info

2

Shimazu T, Horinouchi S, Yoshida M (2007) Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J Biol Chem 282, 4470-8
17172643   Curated Info