Ser389
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Home > Phosphorylation Site Page: > Ser389  -  ELK1 (human)

Site Information
LsPIAPRsPAKLSFQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449757

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 3 ) , [32P] bio-synthetic labeling ( 3 , 4 ) , mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 2 ) , phosphopeptide mapping ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ERK1 (human) ( 3 ) , P38A (human) ( 3 )
Putative in vivo kinases:
ERK1 (human) ( 4 )
Kinases, in vitro:
ERK1 (human) ( 3 , 4 ) , P38A (human) ( 3 )
Treatments:
estradiol ( 1 ) , faslodex ( 1 ) , PD98059 ( 1 ) , phorbol_ester ( 2 ) , serum ( 2 ) , TGF-beta ( 1 )

Downstream Regulation
Effects of modification on ELK1:
activity, induced ( 4 ) , protein conformation ( 4 )
Effects of modification on biological processes:
transcription, altered ( 1 ) , transcription, induced ( 3 , 4 )

References 

1

Duan R, Xie W, Burghardt RC, Safe S (2001) Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. J Biol Chem 276, 11590-8
11145955   Curated Info

2

Cruzalegui FH, Cano E, Treisman R (1999) ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. Oncogene 18, 7948-57
10637505   Curated Info

3

Janknecht R, Hunter T (1997) Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J 16, 1620-7
9130707   Curated Info

4

Janknecht R, Ernst WH, Pingoud V, Nordheim A (1993) Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J 12, 5097-104
8262053   Curated Info