Tyr293
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Home > Phosphorylation Site Page: > Tyr293  -  PSF (human)

Site Information
RRPGEktyTQRCRLF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 482843

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , microscopy-colocalization with upstream kinase ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lymphoma ( 1 ) , anaplastic large cell lymphoma ( 1 )
Relevant cell line - cell type - tissue:
293T (epithelial) ( 1 ) , BaF3 ('B lymphocyte, precursor') ( 1 ) , SU-DHL1 (T lymphocyte) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ALK (human) ( 1 )
Kinases, in vitro:
ALK (human) ( 1 )

Downstream Regulation
Effects of modification on PSF:
intracellular localization ( 1 )
Effects of modification on biological processes:
cell growth, altered ( 1 ) , transcription, altered ( 1 )
Induce interaction with:
RNA ( 1 )

References 

1

Galietta A, et al. (2007) NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma. Blood 110, 2600-9
17537995   Curated Info