Ser44

Site Information
RQRARLVsKDGRCNI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 449605

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:	oocyte ( 1 , 2 , 3 )

Downstream Regulation
Effects of modification on ROMK:	activity, inhibited ( 1 ) , protein processing ( 3 )

References
1	Lee CH, et al. (2008) d-Amphetamine inhibits inwardly rectifying potassium channels in Xenopus oocytes expression system. Neurotoxicology 29, 638-46 18571730 Curated Info
2	Lee CH, Lee CY, Tsai TS, Liou HH (2008) PKA-mediated phosphorylation is a novel mechanism for levetiracetam, an antiepileptic drug, activating ROMK1 channels. Biochem Pharmacol 76, 225-35 18547545 Curated Info
3	O'Connell AD, et al. (2005) Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK). Proc Natl Acad Sci U S A 102, 9954-9 15987778 Curated Info