Lys243
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Home > Acetylation Site Page: > Lys243  -  BUB1B (mouse)

Site Information
SRVGGALkAPGQSRG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7761217

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) [BUB1 (mouse), genetic knockin] ( 2 )

Downstream Regulation
Effects of modification on BUB1B:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 2 ) , cytoskeletal reorganization ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
angiosarcoma ( 2 ) , leukemia ( 2 ) , hepatocellular carcinoma ( 2 ) , non-small cell lung adenocarcinoma ( 2 ) , B cell lymphoma ( 2 )

References 

1

Lee YK, Park I, Lee H (2014) Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis. Endocrinol Metab (Seoul) 29, 561-6
25559578   Curated Info

2

Park I, et al. (2013) Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation. J Cell Biol 202, 295-309
23878276   Curated Info