Ser246
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Home > Phosphorylation Site Page: > Ser246  -  ILK (human)

Site Information
CPRLRIFsHPNVLPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 479407

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 3 , 5 ) , western blotting ( 1 , 2 , 3 , 5 )
Disease tissue studied:
brain cancer ( 5 ) , Schwannoma ( 5 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PARVA (human) ( 3 )
Putative in vivo kinases:
PAK1 (human) ( 4 )
Kinases, in vitro:
PAK1 (human) ( 4 )
Treatments:
E-cadherin-Fc ( 2 ) , OSU-T315 ( 5 ) , QLT0267 ( 2 ) , SB431542 ( 2 ) , SiO2 @AM/CN ( 1 ) , siRNA ( 4 ) , TGF-beta ( 2 ) , wortmannin ( 2 )

Downstream Regulation
Effects of modification on ILK:
intracellular localization ( 4 )
Effects of modification on biological processes:
cell motility, altered ( 4 )

References 

1

Dehghany Ashkezary M, Aboee-Mehrizi F, Moradi P (2017) [email protected] molecules covered by nepetalactone, extracted from Nepeta gloeocephala, inhibits ILK phosphorylation and downstream PKB/AKT signaling in HeLa cells. Cancer Gene Ther 24, 28-32
27982018   Curated Info

2

Boutet M, et al. (2016) TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment. Cancer Res 76, 1757-69
26921343   Curated Info

3

Huang AH, et al. (2015) PARVA Promotes Metastasis by Modulating ILK Signalling Pathway in Lung Adenocarcinoma. PLoS One 10, e0118530
25738875   Curated Info

4

Acconcia F, et al. (2007) Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. Proc Natl Acad Sci U S A 104, 6782-7
17420447   Curated Info

5

Mercado-Pimentel ME, et al. The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation. Austin J Med Oncol 3
27642646   Curated Info