Thr306
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Home > Phosphorylation Site Page: > Thr306  -  CAMK2A (rat)

Site Information
LkGAILttMLAtRNF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449596

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
brain ( 3 ) , neuron-'brain, hippocampus' ( 1 , 2 )

Upstream Regulation
Kinases, in vitro:
CAMK2A (human) ( 7 ) , CAMK2A (rat) ( 4 , 5 , 8 )

Downstream Regulation
Effects of modification on CAMK2A:
enzymatic activity, inhibited ( 7 , 8 ) , molecular association, regulation ( 7 , 8 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )
Inhibit interaction with:
Calmodulin (cow) ( 8 ) , Calmodulin (rat) ( 7 )

References 

1

Pi HJ, et al. (2010) CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action. Proc Natl Acad Sci U S A 107, 14437-42
20660727   Curated Info

2

Pi HJ, et al. (2010) Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylation. J Neurosci 30, 8704-9
20592192   Curated Info

3

Guo A (2007) CST Curation Set: 2239; Year: 2007; Biosample/Treatment: tissue, brain/ischemia 20'; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate Antibody Cat#: 2851
Curated Info

4

Takao K, et al. (2005) Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons. J Neurosci 25, 3107-12
15788767   Curated Info

5

Lengyel I, et al. (2000) Modulation of the phosphorylation and activity of calcium/calmodulin-dependent protein kinase II by zinc. J Neurochem 75, 594-605
10899934   Curated Info

6

Ishida A, Fujisawa H (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J Biol Chem 270, 2163-70
7836445   Curated Info

7

Hanson PI, Schulman H (1992) Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase analyzed by site-directed mutagenesis. J Biol Chem 267, 17216-24
1324926   Curated Info

8

Colbran RJ, Soderling TR (1990) Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. Studies on the effect of phosphorylation of threonine 305/306 and serine 314 on calmodulin binding using synthetic peptides. J Biol Chem 265, 11213-9
2162839   Curated Info