Thr306
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Home > Phosphorylation Site Page: > Thr306  -  CAMK2A (mouse)

Site Information
LkGAILttMLAtRNF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449596

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 5 , 6 , 7 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 , 9 ) , phospho-antibody ( 1 , 9 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 7 ) , 'brain, hippocampus' ( 1 ) , brain ( 4 , 6 ) , HEK293T (epithelial) ( 1 ) , liver ( 5 ) , MEF (fibroblast) ( 3 ) , neuron-'brain, hippocampus' ( 9 ) , neuron:postsynaptic density-'brain, hippocampus, CA1 region' ( 2 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Kinases, in vitro:
CAMK2A (mouse) ( 8 )
Putative upstream phosphatases:
PTEN (human) ( 1 )
Phosphatases, in vitro:
PTEN (human) ( 1 )
Treatments:
EGTA ( 9 ) , long-term_potentiation ( 2 )

Downstream Regulation
Effects of modification on CAMK2A:
enzymatic activity, inhibited ( 1 ) , intracellular localization ( 1 , 9 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Inhibit interaction with:
Calmodulin (human) ( 1 ) , NMDAR2B (human) ( 1 )

References 

1

Wang P, et al. (2017) PTENα Modulates CaMKII Signaling and Controls Contextual Fear Memory and Spatial Learning. Cell Rep 19, 2627-2641
28636948   Curated Info

2

Li J, et al. (2016) Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Sci Signal 9, rs8
27507650   Curated Info

3

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

4

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

5

Guo A (2011) CST Curation Set: 12478; Year: 2011; Biosample/Treatment: tissue, liver/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

6

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

7

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

8

Leonard AS, et al. (2002) Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin and alpha-actinin. J Biol Chem 277, 48441-8
12379661   Curated Info

9

Elgersma Y, et al. (2002) Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron 36, 493-505
12408851   Curated Info