Thr1008
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Home > Phosphorylation Site Page: > Thr1008  -  BUB1B (human)

Site Information
LNANDEAtVSVLGEL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7652107

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 2 )
Kinases, in vitro:
PLK1 (human) ( 2 )
Treatments:
AZ3146 ( 1 ) , BI2536 ( 1 ) , SP600125 ( 1 ) , ZM447439 ( 1 )

Downstream Regulation
Effects of modification on BUB1B:
enzymatic activity, induced ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )

References 

1

Tipton AR, et al. (2013) Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex. J Biol Chem 288, 35149-58
24151075   Curated Info

2

Matsumura S, Toyoshima F, Nishida E (2007) Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1. J Biol Chem 282, 15217-27
17376779   Curated Info