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Site Information |
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AtRIPAktPPAPktP SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 449077 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Kinases, in vitro: |
Downstream Regulation | |
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Effects of modification on Tau iso8: | |
Effects of modification on biological processes: | |
Inhibit interaction with: |
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Relevant diseases: |
References | |
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Jeong J, et al. (2020) JBPOS0101 regulates amyloid beta, tau, and glial cells in an Alzheimer's disease model. PLoS One
32791516 Curated Info |
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Moszczynski AJ, et al. (2018) Pathologic Thrtau phosphorylation in CTE and CTE with ALS. Neurology 90, e380-e387
29298849 Curated Info |
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Qi H, et al. (2016) Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase. J Biol Chem 291, 7742-53
26858248 Curated Info |
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Moszczynski AJ, et al. (2015) Thr(175)-phosphorylated tau induces pathologic fibril formation via GSK3β-mediated phosphorylation of Thr(231) in vitro. Neurobiol Aging 36, 1590-9
25573097 Curated Info |
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Gohar M, et al. (2009) Tau phosphorylation at threonine-175 leads to fibril formation and enhanced cell death: implications for amyotrophic lateral sclerosis with cognitive impairment. J Neurochem 108, 634-43
19046355 Curated Info |
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Hanger DP, et al. (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-54
17562708 Curated Info |
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Schneider A, et al. (1999) Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry 38, 3549-58
10090741 Curated Info |
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Hanger DP, et al. (1998) New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J Neurochem 71, 2465-76
9832145 Curated Info |
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Illenberger S, et al. (1998) The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. Mol Biol Cell 9, 1495-512
9614189 Curated Info |