Ser443
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Home > Phosphorylation Site Page: > Ser443  -  Cot (mouse)

Site Information
EVLRRQRsLYIDLGA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478514

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , macrophage-bone marrow ( 1 )

Upstream Regulation
Putative in vivo kinases:
Cot (human) ( 1 )
Treatments:
BI605906 ( 1 ) , IL-1b ( 1 ) , Tpl2_inhibitor ( 1 )

Downstream Regulation
Effects of modification on Cot:
molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )
Induce interaction with:
14-3-3 gamma (human) ( 1 ) , 14-3-3 zeta (human) ( 1 )

References 

1

Ben-Addi A, et al. (2014) IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases. Proc Natl Acad Sci U S A 111, E2394-403
24912162   Curated Info