Ser868

Site Information
MVEELRMsLKCQRRL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 478417

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:	'neuron, cortical' ( 3 ) , 'neuron, hippocampal' ( 3 ) , 293 (epithelial) ( 2 ) , COS (fibroblast) ( 3 ) , neuron-'brain, hippocampus' ( 1 )

Downstream Regulation
Effects of modification on GluR6:	molecular association, regulation ( 2 ) , receptor recycling, inhibited ( 1 ) , sumoylation ( 3 )
Effects of modification on biological processes:	endocytosis, induced ( 3 ) , exocytosis, inhibited ( 1 )
Induce interaction with:	14-3-3 theta (human) ( 2 )

References
1	Evans AJ, et al. (2017) Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity. Cell Rep 19, 2613-2626 28636947 Curated Info
2	Sun C, et al. (2013) Modulation of GluK2a Subunit-containing Kainate Receptors by 14-3-3 Proteins. J Biol Chem 288, 24676-90 23861400 Curated Info
3	Konopacki FA, et al. (2011) Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Proc Natl Acad Sci U S A 108, 19772-7 22089239 Curated Info
4	Kornreich BG, Niu L, Roberson MS, Oswald RE (2007) Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of kainate receptor subtype 6. Neuroscience 146, 1158-68 17379418 Curated Info