Ser844

Site Information
GsGsEAAsLSsLNsS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 478354

In vivo Characterization
Methods used to characterize site in vivo:	electrophoretic mobility shift ( 1 ) , microscopy-colocalization with upstream kinase ( 3 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 1 )
Disease tissue studied:	breast cancer ( 3 )
Relevant cell line - cell type - tissue:	E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 ) , L929 (fibroblast) ( 3 ) , MCF-7 (breast cell) ( 3 ) , MDCK (epithelial) ( 3 )

Downstream Regulation
Effects of modification on CDH1:	intracellular localization ( 3 ) , molecular association, regulation ( 3 ) , protein stabilization ( 1 )
Effects of modification on biological processes:	carcinogenesis, altered ( 1 ) , cell adhesion, altered ( 3 ) , cell motility, inhibited ( 1 )
Inhibit interaction with:	CTNNB1 (human) ( 3 )

References
1	Koshino A, et al. (2021) PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer. Front Pharmacol 12, 772926 35115926 Curated Info
2	Inuzuka H, et al. (2012) Acetylation-dependent regulation of skp2 function. Cell 150, 179-93 22770219 Curated Info
3	Dupre-Crochet S, et al. (2007) Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts. Mol Cell Biol 27, 3804-16 17353278 Curated Info