Lys126
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Home > Acetylation Site Page: > Lys126  -  BACE (human)

Site Information
STYRDLRkGVYVPYT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478256

In vivo Characterization
Methods used to characterize site in vivo:
[14C] acetate labeling ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Disease tissue studied:
colorectal cancer ( 1 ) , neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on BACE:
intracellular localization ( 2 ) , protein stabilization ( 2 )

References 

1

Li Y (2008) CST Curation Set: 4817; Year: 2008; Biosample/Treatment: tissue, colon/untreated; Disease: colorectal cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989
Curated Info

2

Costantini C, Ko MH, Jonas MC, Puglielli L (2007) A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1. Biochem J 407, 383-95
17425515   Curated Info