Tyr365
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Home > Phosphorylation Site Page: > Tyr365  -  AR (human)

Site Information
AyQSRDyyNFPLALA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 478251

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 3 , 4 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 1 , 2 )
Disease tissue studied:
prostate cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Ack (human) ( 1 , 3 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, altered ( 3 ) , transcription, induced ( 3 )

References 

1

De Silva D, et al. (2019) Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. Sci Rep 9, 18637
31819114   Curated Info

2

Karaca M, et al. (2015) Mutation of androgen receptor N-terminal phosphorylation site tyr-267 leads to inhibition of nuclear translocation and DNA binding. PLoS One 10, e0126270
25950519   Curated Info

3

Mahajan NP, et al. (2007) Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proc Natl Acad Sci U S A 104, 8438-43
17494760   Curated Info

4

Guo Z, et al. (2006) Regulation of androgen receptor activity by tyrosine phosphorylation. Cancer Cell 10, 309-19
17045208   Curated Info