Ser75

Site Information
sPsRLSKsQGGEDES SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 477954

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:	'3T3-L1, differentiated' (adipocyte) ( 2 ) , heart ( 3 ) , macrophage-peritoneum ( 4 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 4 ) , MC3T3-E1 (preosteoblast) ( 1 )

Upstream Regulation
Regulatory protein:	ADRB1 (mouse) ( 3 )
Treatments:	insulin ( 2 ) , LY294002 ( 2 ) , MK-2206 ( 2 )

References
1	Williams GR, et al. (2016) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods 92, 36-50 26160508 Curated Info
2	Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20 23684622 Curated Info
3	Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11 23737553 Curated Info
4	Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51 22942356 Curated Info