Thr219

Site Information
AEHQYFMtEyVATRW SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448205

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:	brain cancer ( 3 ) , glioma ( 3 )
Relevant cell line - cell type - tissue:	'neuron, cerebellar granule' ( 1 ) , C6 (glial) ( 3 ) , spinal cord ( 2 )

Upstream Regulation
Treatments:	BIX02188 ( 2 ) , etoposide ( 3 ) , morphine ( 2 ) , morphine_withdrawal ( 2 ) , NSC23766 ( 1 ) , TeTx ( 1 )

References
1	Stankiewicz TR, et al. (2015) Neuronal Apoptosis Induced by Selective Inhibition of Rac GTPase versus Global Suppression of Rho Family GTPases Is Mediated by Alterations in Distinct Mitogen-activated Protein Kinase Signaling Cascades. J Biol Chem 290, 9363-76 25666619 Curated Info
2	Wang CG, et al. (2011) Activation of the spinal extracellular signal-regulated kinase 5 signaling pathway contributes to morphine physical dependence in rats. Neurosci Lett 494, 38-43 21356274 Curated Info
3	Lomonaco SL, et al. (2008) Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide. J Biol Chem 283, 17731-9 18434324 Curated Info