Ser231

Site Information
SLtPEIVstPssPEE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 7103756

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 )
Disease tissue studied:	breast cancer ( 3 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 4 ) , BT-20 (breast cell) ( 3 ) , BT-549 (breast cell) ( 3 ) , Calu 6 (pulmonary) ( 3 ) , H2009 (pulmonary) ( 3 ) , H2077 (pulmonary) ( 3 ) , H2887 (pulmonary) ( 3 ) , H322M (pulmonary) ( 3 ) , HCC1937 (breast cell) ( 3 ) , HCC366 (pulmonary) ( 3 ) , HCC78 (pulmonary) ( 3 ) , HeLa (cervical) ( 1 ) , HOP62 (pulmonary) ( 3 ) , Jurkat (T lymphocyte) ( 5 ) , K562 (erythroid) ( 2 ) , MCF-7 (breast cell) ( 3 ) , MDA-MB-231 (breast cell) ( 3 ) , MDA-MB-468 (breast cell) ( 3 ) , NCI-H1395 (pulmonary) ( 3 ) , NCI-H1648 (pulmonary) ( 3 ) , NCI-H2030 (pulmonary) ( 3 ) , NCI-H322 (pulmonary) ( 3 )

References
1	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
2	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501 19413330 Curated Info
5	Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46 19690332 Curated Info