Ser376
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Home > Phosphorylation Site Page: > Ser376  -  SLP76 (human)

Site Information
SSFPQsAsLPPYFSQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 476784

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
leukemia ( 2 ) , T cell leukemia ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 , 3 ) , Jurkat (T lymphocyte) ( 2 , 4 ) , T lymphocyte ( 1 )

Upstream Regulation
Regulatory protein:
CD28 (human) ( 1 ) , HPK1 (human) ( 3 ) , ROR1 (human) ( 1 ) , SCT (human) ( 1 )
Putative in vivo kinases:
HPK1 (human) ( 2 , 4 )
Kinases, in vitro:
HPK1 (human) ( 4 )
Treatments:
antibody ( 4 ) , antigenic stimulation ( 1 ) , calyculin_A ( 4 ) , virus infection ( 1 )

Downstream Regulation
Effects of modification on SLP76:
molecular association, regulation ( 2 , 4 ) , protein degradation ( 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
transcription, altered ( 4 )
Induce interaction with:
14-3-3 epsilon (human) ( 4 ) , 14-3-3 gamma (human) ( 2 ) , 14-3-3 zeta (human) ( 4 )

References 

1

Salter AI, et al. (2021) Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function. Sci Signal 14
34429382   Curated Info

2

Wang X, et al. (2012) Attenuation of T Cell Receptor Signaling by Serine Phosphorylation-mediated Lysine 30 Ubiquitination of SLP-76 Protein. J Biol Chem 287, 34091-100
22902619   Curated Info

3

Chuang HC, et al. (2011) The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nat Immunol 12, 1113-8
21983831   Curated Info

4

Di Bartolo V, et al. (2007) A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med 204, 681-91
17353368   Curated Info