Ser231
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Home > Phosphorylation Site Page: > Ser231  -  NDEL1 (human)

Site Information
GTENTFPsPKAIPNG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 474507

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 12 ) , mass spectrometry ( 2 , 3 , 4 , 6 , 8 , 9 , 10 , 11 ) , mutation of modification site ( 1 , 12 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 ) , melanoma skin cancer ( 3 ) , FTLD ( 11 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 11 ) , breast ( 2 ) , HEK293T (epithelial) ( 12 ) , HeLa (cervical) ( 4 , 8 , 9 , 10 ) , Jurkat (T lymphocyte) ( 6 ) , K562 (erythroid) ( 8 ) , SF9 ( 1 ) , WM239A (melanocyte) ( 3 )

Upstream Regulation
Treatments:
nocodazole ( 12 ) , vemurafenib ( 3 )

Downstream Regulation
Effects of modification on NDEL1:
intracellular localization ( 12 ) , molecular association, regulation ( 1 , 12 )
Induce interaction with:
DYNC1I1 (human) ( 1 ) , PAFAH1B1 (human) ( 12 )

References 

1

Garrott SR, et al. (2023) Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways. J Biol Chem 299, 104735
37086789   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

4

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

5

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

6

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

7

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

8

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

9

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

10

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

11

Herskowitz JH, et al. (2010) Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration. J Proteome Res 9, 6368-79
20886841   Curated Info

12

Yan X, et al. (2003) Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. Mol Cell Biol 23, 1239-50
12556484   Curated Info

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