Ser119
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Home > Phosphorylation Site Page: > Ser119  -  ITPKA (rat)

Site Information
LQQPRRLsTSSLSST   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4763186

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal' ( 1 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Kinases, in vitro:
PKACA (human) ( 1 )
Treatments:
H-89 ( 1 ) , long-term_potentiation ( 1 ) , NKH_477 ( 1 )

Downstream Regulation
Effects of modification on ITPKA:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 ) , neural plasticity ( 1 )
Inhibit interaction with:
EB3 (human) ( 1 )

References 

1

Mo SJ, et al. (2019) PKA-dependent phosphorylation of IP3K-A at Ser119 regulates a binding affinity with EB3. Biochem Biophys Res Commun 508, 52-59
30466786   Curated Info