Tyr163
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Home > Phosphorylation Site Page: > Tyr163  -  FLOT2 (rat)

Site Information
DVyDKVDyLSSLGKT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 475941

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
adrenal cancer ( 2 ) , pheochromocytoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 2 )
Treatments:
AG1478 ( 2 ) , EGF ( 1 , 2 ) , PP1 ( 2 ) , PP2 ( 2 ) , PP3 ( 2 ) , SU6656 ( 2 ) , vanadate ( 2 )

Downstream Regulation
Effects of modification on FLOT2:
intracellular localization ( 1 , 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell motility, altered ( 2 ) , cytoskeletal reorganization ( 2 )
Induce interaction with:
FLOT1 (rat) ( 1 )

References 

1

Babuke T, et al. (2009) Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. Cell Signal 21, 1287-97
19318123   Curated Info

2

Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R (2007) Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J Cell Sci 120, 395-406
17213334   Curated Info