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Site Information |
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MMRsKETssPGtDDV SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 475073 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Kinases, in vitro: | |
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Downstream Regulation | |
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Effects of modification on NHE1: |
References | |
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Amith SR, Wilkinson JM, Fliegel L (2016) Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells. Oncotarget 7, 21091-113
27049728 Curated Info |
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Li X, Khan MF, Schriemer DC, Fliegel L (2013) Structural changes in the C-terminal regulatory region of the Na(+)/H(+) exchanger mediate phosphorylation induced regulation. J Mol Cell Cardiol 61, 153-63
23602949 Curated Info |
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Odunewu A, Fliegel L (2013) Acidosis-mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells. Am J Physiol Renal Physiol 305, F370-81
23678047 Curated Info |
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Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648 Curated Info |
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Malo ME, Li L, Fliegel L (2007) Mitogen-activated protein kinase-dependent activation of the Na+/H+ exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771. J Biol Chem 282, 6292-9
17209041 Curated Info |
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Liu H, et al. (2004) Open tubular immobilized metal ion affinity chromatography combined with MALDI MS and MS/MS for identification of protein phosphorylation sites. Anal Chem 76, 4223-32
15253667 Curated Info |