Ser529
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Home > Phosphorylation Site Page: > Ser529  -  DYRK1A (human)

Site Information
SNSGRARsDPtHQHR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 475065

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 6 ) , immunoprecipitation ( 6 ) , mass spectrometry ( 1 , 3 , 4 ) , mutation of modification site ( 6 ) , phospho-antibody ( 5 , 6 ) , western blotting ( 5 , 6 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 5 , 6 ) , A498 (renal) ( 4 ) , HeLa_Meta (cervical) ( 3 ) , HeLa_Pro (cervical) ( 3 ) , HeLa_Telo (cervical) ( 3 ) , liver ( 1 ) , U2OS (bone cell) ( 6 )

Upstream Regulation
Putative in vivo kinases:
DYRK1A (human) ( 6 )
Treatments:
FGF2 ( 6 ) , harmine ( 5 ) , MG132_withdrawal ( 3 ) , SB216763 ( 6 )

Downstream Regulation
Effects of modification on DYRK1A:
enzymatic activity, induced ( 6 ) , molecular association, regulation ( 6 )
Induce interaction with:
14-3-3 beta (human) ( 6 )

References 

1

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

2

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

3

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info

4

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

5

Laguna A, et al. (2008) The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev Cell 15, 841-53
19081073   Curated Info

6

Alvarez M, Altafaj X, Aranda S, de la Luna S (2007) DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding. Mol Biol Cell 18, 1167-78
17229891   Curated Info