Ser11

Site Information
NDDIEVEsDADKRAH SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 449308

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 11 ) , immunoprecipitation ( 11 ) , mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 , 9 , 10 ) , mutation of modification site ( 11 ) , phosphopeptide mapping ( 11 )
Disease tissue studied:	breast cancer ( 5 ) , breast ductal carcinoma ( 5 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 5 ) , cervical cancer ( 10 ) , cervical adenocarcinoma ( 10 ) , lung cancer ( 7 ) , non-small cell lung cancer ( 7 ) , melanoma skin cancer ( 3 )
Relevant cell line - cell type - tissue:	293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 9 ) , breast ( 1 , 5 ) , COS (fibroblast) ( 11 ) , HCC366 (pulmonary) ( 7 ) , HCC78 (pulmonary) ( 7 ) , HCC827 (pulmonary) ( 7 ) , HeLa (cervical) ( 4 ) , HeLa S3 (cervical) ( 10 ) , Jurkat (T lymphocyte) ( 6 ) , LCLC-103H (pulmonary) ( 7 ) , MEF (fibroblast) ( 11 ) , NCI-H1395 (pulmonary) ( 7 ) , NCI-H2030 (pulmonary) ( 7 ) , WM239A (melanocyte) ( 3 )

Downstream Regulation
Effects of modification on MAX iso2:	activity, inhibited ( 11 )
Effects of modification on biological processes:	transcription, altered ( 11 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610 27184836 Curated Info
3	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
4	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
5	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
6	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
7	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
8	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
9	Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53 20363803 Curated Info
10	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
11	Koskinen PJ, et al. (1994) Max activity is affected by phosphorylation at two NH2-terminal sites. Cell Growth Differ 5, 313-20 8018564 Curated Info