Lys120
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Acetylation Site Page: > Lys120  -  p53 (human)

Site Information
FLhSGTAkSVTCTyS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 474514

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 26 ) , mutation of modification site ( 9 , 25 , 26 ) , phospho-antibody ( 9 ) , western blotting ( 9 )
Disease tissue studied:
colorectal cancer ( 9 , 26 ) , colorectal carcinoma ( 9 , 26 ) , lung cancer ( 25 , 26 ) , non-small cell lung cancer ( 25 , 26 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
etoposide ( 9 ) , KN-92 ( 9 ) , KN-93 ( 9 ) , nicotinamide ( 26 ) , tiron ( 9 ) , trichostatin_A ( 26 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 9 , 26 ) , transcription, altered ( 25 , 26 ) , transcription, induced ( 9 )

References 

1

Choi OR, Ryu MS, Lim IK (2016) Shifting p53-induced senescence to cell death by TIS21(/BTG2/Pc3) gene through posttranslational modification of p53 protein. Cell Signal 28, 1172-85
27208501   Curated Info

2

Davaadelger B, et al. (2016) Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor. Oncotarget 7, 27511-26
27050276   Curated Info

3

Yun T, et al. (2016) Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway. J Biol Chem 291, 7386-95
26851285   Curated Info

4

Liu X, et al. (2016) NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep 17, 349-66
26882543   Curated Info

5

Leszczynska KB, et al. (2015) Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. J Clin Invest 125, 2385-98
25961455   Curated Info

6

Xu Y, et al. (2014) Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage. Oncotarget 5, 12555-72
25544752   Curated Info

7

Zhang ZN, Chung SK, Xu Z, Xu Y (2014) Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells 32, 157-65
24038750   Curated Info

8

Chang J, et al. (2013) Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J 32, 3192-205
24219989   Curated Info

9

Sen N, Kumari R, Singh MI, Das S (2013) HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress. Mol Cell 52, 406-20
24120667   Curated Info

10

Kim SS, Benchimol S (2013) HDAC5--a critical player in the p53 acetylation network. Mol Cell 52, 289-90
24207022   Curated Info

11

Dai C, Shi D, Gu W (2013) Negative Regulation of the Acetyltransferase TIP60-p53 Interplay by UHRF1 (Ubiquitin-like with PHD and RING Finger Domains 1). J Biol Chem 288, 19581-92
23677994   Curated Info

12

Liu N, et al. (2013) ING5 Is a Tip60 Cofactor That Acetylates p53 in Response to DNA Damage. Cancer Res 73, 3749-60
23576563   Curated Info

13

Zheng H, et al. (2013) A Posttranslational Modification Cascade Involving p38, Tip60, and PRAK Mediates Oncogene-Induced Senescence. Mol Cell 50, 699-710
23685072   Curated Info

14

Rokudai S, et al. (2013) MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A 110, 3895-900
23431171   Curated Info

15

Dai C, et al. (2011) Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. Proc Natl Acad Sci U S A 108, 18937-42
22084066   Curated Info

16

Charvet C, et al. (2011) Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell 42, 584-96
21658600   Curated Info

17

Sho T, et al. (2011) TRIM29 negatively regulates p53 via inhibition of Tip60. Biochim Biophys Acta 1813, 1245-53
21463657   Curated Info

18

Arbely E, et al. (2011) Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration. Proc Natl Acad Sci U S A 108, 8251-6
21525412   Curated Info

19

Chen X, Wong JY, Wong P, Radany EH (2011) Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis. Mol Cancer Res 9, 448-61
21303901   Curated Info

20

Mellert HS, et al. (2011) Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. J Biol Chem 286, 4264-70
21148320   Curated Info

21

Li X, et al. (2009) Two mammalian MOF complexes regulate transcription activation by distinct mechanisms. Mol Cell 36, 290-301
19854137   Curated Info

22

Sykes SM, et al. (2009) Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem 284, 20197-205
19494119   Curated Info

23

Shinmen N, et al. (2009) Activation of NFAT signal by p53-K120R mutant. FEBS Lett 583, 1916-22
19416725   Curated Info

24

Wu SY, Chiang CM (2009) Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. EMBO J 28, 1246-59
19339993   Curated Info

25

Tian C, et al. (2009) KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol 11, 580-91
19377469   Curated Info

26

Tang Y, et al. (2008) Acetylation is indispensable for p53 activation. Cell 133, 612-26
18485870   Curated Info

27

Mellert H, Sykes SM, Murphy ME, McMahon SB (2007) The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle 6, 1304-6
17534149   Curated Info

28

Sykes SM, et al. (2006) Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 24, 841-51
17189187   Curated Info