Ser251
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Home > Phosphorylation Site Page: > Ser251  -  NDEL1 (mouse)

Site Information
LtPSARIsALNIVGD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 474509

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) [IGF1R (mouse)] ( 2 )

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 2 )
Kinases, in vitro:
AurA (human) ( 1 , 2 )
Treatments:
MG132 ( 2 )

Downstream Regulation
Effects of modification on NDEL1:
intracellular localization ( 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Okamoto M, et al. (2015) DBZ Regulates Cortical Cell Positioning and Neurite Development by Sustaining the Anterograde Transport of Lis1 and DISC1 through Control of Ndel1 Dual-Phosphorylation. J Neurosci 35, 2942-58
25698733   Curated Info

2

Mori D, et al. (2007) NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol 27, 352-67
17060449   Curated Info

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