Ser231
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Home > Phosphorylation Site Page: > Ser231  -  NDEL1 (mouse)

Site Information
GTENSFPsPKAIPNG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 474507

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 5 , 7 ) , mutation of modification site ( 6 ) , phospho-antibody ( 6 , 8 ) , western blotting ( 6 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 2 ) , 'brain, forebrain' ( 8 ) , 'brain, forebrain' [CDK5R1 (mouse), transgenic] ( 8 ) , 3T3 (fibroblast) ( 6 ) , brain ( 3 , 4 , 5 ) , COS (fibroblast) ( 6 ) , MEF (fibroblast) [IGF1R (mouse)] ( 7 )

Upstream Regulation
Kinases, in vitro:
CDK5 (human) ( 7 )

Downstream Regulation
Effects of modification on NDEL1:
activity, induced ( 6 ) , intracellular localization ( 6 )
Effects of modification on biological processes:
cell motility, altered ( 6 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

3

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

4

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

5

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

6

Shen Y, et al. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell 14, 342-53
18331715   Curated Info

7

Mori D, et al. (2007) NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol 27, 352-67
17060449   Curated Info

8

Cruz JC, et al. (2003) Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40, 471-83
14642273   Curated Info

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