Ser388
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Home > Phosphorylation Site Page: > Ser388  -  p73 (human)

Site Information
VPQPLVDsYRQQQQL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6417400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , small-cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
NCI-H82 (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 ) , PKCB iso2 (human) ( 1 )
Treatments:
PKC412 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on p73:
activity, induced ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , transcription, altered ( 1 )

References 

1

Nyman U, et al. (2009) Protein kinase C-dependent phosphorylation regulates the cell cycle-inhibitory function of the p73 carboxy terminus transactivation domain. Mol Cell Biol 29, 1814-25
19158275   Curated Info

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